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Journal of Biotechnology & Biomaterials | ISSN: 2155-952X | Volume: 8
July 23-24, 2018 | Vancouver, Canada
Annual Biotechnology Congress
Nanoscale organization of polymer-nanoparticle assemblies: From biological nanopores to smart polymers
N
uclear Pore Complex (NPC) is a key cellular transporter that spans the nuclear envelope and controls nucleocytoplasmic
transport in eukaryotic cells. NPC is involved in large number of regulatory processes. It is a remarkable device that
robustly carries highly selective and rapid macromolecular transport. NPC transport mechanism has inspired creation of
selective bio-mimetic nanopores for bio-nano-technology applications. The centerpiece of the NPC transport is the assembly of
polymer-like intrinsically disordered polypeptides that line its passageway. The conformational dynamics of these polymer-like
molecules and their interactions cargo-carrying transport proteins underlie the NPC ability to selectively transport hundreds
of cargoes per second in crowded and noisy cellular environment. I will present recent insights into the organization and
function of the NPC and man-made polymer-functionalized channels and surfaces, arising from systematic comparison of
computational and theoretical results with experimental data, and discuss how these results suggest strategies for creation of
selective stimuli-responsive nanomaterials.
Biography
Anton Zilman was trained as a Physicist and currently his group works on a number of problems on the interface of physics, biology and engineering.
zilmana@physics.utoronto.caAnton Zilman
University of Toronto, Canada
Anton Zilman, J Biotechnol Biomater 2018, Volume: 8
DOI: 10.4172/2155-952X-C3-093