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Analytica 2016
September 28-30, 2016
Volume 7, Issue 5(Suppl) J Anal Bioanal Tech 2016
ISSN: 2155-9872 JABT, an open access journal
conferenceseries .com
September 28-30, 2016 Orlando, USA
7th International Conference and Exhibition on
Analytical & Bioanalytical Techniques
J Anal Bioanal Tech 2016, 7:5(Suppl)
Non-intrusive blood glucose sensor technology overview
Marc Rippen
Alertgy LLC, USA
C urrent glucose monitoring devices are based on devices originally created in the 1960’s. They have been made smaller are
easier to use and can log data, their measurements basically are the same as the first laboratory sensors. The patent must
prick their finger so that they can squeeze a droplet of blood on a strip coated with an enzyme (usually glucose oxidase) that
reacts to form hydrogen peroxide from the available glucose and oxygen. The hydrogen peroxide generated is then measured
amperometrically with an electrode.The cost, inconvenience and pain incurred in using these systems have led to heavy research
to develop non-invasive glucose monitoring techniques. The major current areas of research and the sensor technologies
they use will be discussed. The techniques to be covered include interstitial fluid chemical analysis, breath chemical analysis,
infrared spectroscopy, optical coherence tomography, temperature modulated localized reflectance, Raman spectroscopy,
polarity changes, ultrasound, fluorescence, thermal spectroscopy, ocular spectroscopy and impedance spectroscopy.
Development of new ion source/new desorption method for mass spectrometry
Md Ahsan Habib
University of Tokyo, Japan
Detection and quantification of illicit compounds at trace level is very much important for public health, security and safety.
Mass spectrometry (MS) has already been demonstrated its versatility for detection and quantification of a wide range
of compounds at trace level because MS can provide molecular level information of the target compounds. So far, none of the
ion source can ionize efficiently for a wide range of compounds. For example, electrospray ionization (ESI) and nano-ESI have
been widely using for bio-molecules. Nano-ESI has shown better resolution than ESI but it has clogging problem. To overcome
such a problem, several attempts have been taken to develop new ionization source, for example, MALDI, DESI, probe-ESI
(PESI) etc. Recently, we have developed new atmospheric pressure chemical ionization (APCI) using alternating current (ac)
instead of dc and found as a soft ionization source. Moreover, hollow cathode discharge (HCD) ionization source has been
fabricated for detection of explosives at trace level. A desorption method has also been developed using an ultra-cutter to
desorb highly non-volatile illicit compounds and ionized dielectric discharge (DBD) ionization source and found better limit
of detection (LOD). A vacuum glow discharge ionization (vacuum-GDI) source has been fabricated for compounds those give
negative ions. A further attempt has also been taken to fabricate a hybrid ionization source with DBD/ESI for polar/non-polar,
volatile/non-volatile compounds.