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Volume 7, Issue 5(Suppl) J Anal Bioanal Tech 2016
ISSN: 2155-9872 JABT, an open access journal
Page 37
Analytica 2016
September 28-30, 2016
conferenceseries.com
September 28-30, 2016 Orlando, USA
7th International Conference and Exhibition on
Analytical & Bioanalytical Techniques
Peter J Baugh, J Anal Bioanal Tech 2016, 7:5(Suppl)
Comprehensive insights into tobacco smoke using TD-GCxGC-TOF MS with tandem ionization
The hazardous constituents of cigarette smoke have attracted considerable attention lately, especially with increasing
regulation around the world limiting or banning smoking in public places and even in private cars if children are present.
From an analytical perspective, however, there is much that remains to be learnt about the composition of cigarette smoke;
because of its high degree of complexity-tobacco smoke is thought to contain thousands of components acrossmultiple chemical
classes and wide concentration ranges. Comprehensive two-dimensional gas chromatography (GC×GC), when coupled with
time-of-flight mass spectrometry (TOF MS), has been shown to provide improved chemical fingerprinting of complex samples
in areas of study as diverse as petrochemical analysis and fragrance profiling. However, commonly-used thermal modulation
devices are unable to successfully modulate the most volatile components. In this study, we use thermal desorption (TD)
for collection and analysis of whole cigarette emissions, and couple it with flow-modulated GC×GC-TOF MS, to enable the
constituents of whole smoke to be routinely and confidently sampled, separated and identified. The use of novel tandem
ionization is also harnessed to increase the analytical resolution of the system, by providing both reference-quality 70 eV
spectra and soft electron ionization (EI) spectra simultaneously in a single analysis. The complementary soft EI spectra provide
a powerful means of identifying compounds that exhibit similar mass spectral characteristics (or extreme fragmentation) at
conventional 70 eV energies, but without the inconvenience typically associated with conventional soft ionization techniques.
Biography
Peter J Baugh is currently the Environmental and Food Analysis Special Interest Group Leader for British Mass Spectrometry Society. He has published over 70
papers in a variety of Radiation and Environmental fields and in respected journals.
Peter J Baugh
Markes International Ltd, UK