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Volume 08

Journal of Alzheimers Disease & Parkinsonism

Alzheimer's Congress 2018

May 30-31, 2018

May 30-31, 2018 Osaka, Japan

10

th

World Congress on

Alzheimer's Disease & Dementia

Novel therapeutic strategies for alzheimer’s disease: Neurotrophy and neurorestoration

Jun Liu

Sun Yat-sen University, China

A

lzheimer’sDisease(AD)isaneurodegenerativedisordermainlycharacterizedbyβ-amyloiddeposit,τ-hyperphosphorylation

and neuron loss with no curative treatments. In recent years, the main efforts of multinational pharmaceutical companies

have been focused on reducing the aggregation of Aβ and τ-proteins but with repeated defeats. According to statistics of Adis

R&D, between 1998 and 2014, major pharmaceutical companies launched a total of 123 drugs for AD but only three drugs and

one combination therapy program have been approved by the FDA. However, without exception, none of these 123 drugs can

cure AD and even delay the progression of the disease. So we should shift our focus from alleviating the AD-like pathologies

to neuroprotection, which means the preservation of neuronal structure and/or function. As far as we know, there are some

therapeutic strategies of neuroprotection for AD, such as the application of NMDA receptor antagonists, Acetylcholinesterase

Inhibitors (ACEIs), anti-inflammatory agents, antioxidants, neurotrophins and Chinese medicine and so on. Our research

group has found that neurotropin (a non-protein bioactive agent extracted from rabbit inflamed skins inoculated with Vaccinia

virus vaccine), GQDG (Graphene Quantum Dot Conjugated with neuroprotective peptide-glycine-proline-glutamate),

edaravone, EGb761 (

Ginkgo Biloba

extract) and β-sitosterol exerted potent neuroprotective effects in AD. In conclusion, a

single cure for AD is unlikely to be found and multi-target therapies should be addressed.

Biography:

Jun Liu has completed his PhD from Sun Yat-sen University and Postdoctoral studies from University of Kansas Medical School. He is currently the Vice Director

of Neurology Department of Sun Yat-sen Memorial Hospital, Sun Yat-sen University. He has been investigating the pathologies and therapeutics of Alzheimer’s

disease and published more than 22 SCI papers as the corresponding author.

docliujun@hotmail.com

Jun Liu, J Alzheimers Dis Parkinsonism 2018, Volume 8

DOI: 10.4172/2161-0460-C4-045