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Volume 08 Journal of Alzheimers Disease & Parkinsonism Alzheimer's Congress 2018
May 30-31, 2018
Page 13
Notes:
conferenceseries.com
May 30-31, 2018 Osaka, Japan
10th World Congress on
Alzheimer's Disease & Dementia
The association between BDNF gene polymorphisms and cerebrospinal fluid biomarkers in alzheimer’s
disease
Alzheimer’s disease is irreversible neurodegenerative progressive disorder, with complex and multifactorial etiology and the
most frequent cause of dementia worldwide. The more frequent form is a sporadic or Late-Onset AD (LOAD). Besides
older age, other numerous risk factors for LOAD are various risk genotypes, and among them are genes for Brain Derived
Neurotrophic Factor (BDNF) and its receptor Tropomyosin-related kinase B (TrkB), that code proteins involved in modulation
of brain plasticity, neuronal growth, survival, function, regeneration but also apoptosis. Reduced levels of the central and
peripheral BDNF have been found in various neurodegenerative and psychiatric disorders, including LOAD. Risk factors for
LOAD might provoke earlier onset, duration, severity and progress of AD. At present there is no cure for AD. Therefore a quest
for validated, specific and sensitive biomarkers is an unmet need of the AD research. The aim of the study was to evaluate the
association of BDNF (rs6265, rs11030104, rs7934165, rs1519480, C270T) and TrkB (NTRK2) gene polymorphisms with the
Cerebrospinal Fluid (CSF) biomarkers (Aβ1-42, total tau, p-tau181, p-tau199, p-tau231 and the visinin-like protein VILIP-1
(VILIP-1) of LOAD. The diagnosis of probable LOAD (N=114) was made according to the DSM-IV and the NINDS-ADRDA
criteria. Our results revealed significant differences in total tau, p-tau181 and VILIP-1 concentrations in patients subdivided
according to the BDNF rs6265, rs11030104, rs11030104, rs7934165 and C270T genotypes and different p-tau181, p-tau199
and VILIP-1 concentration in carriers of the NTRK2 genotypes. These results reveal a significant association between BDNF
and CSF biomarkers in LOAD.
Biography
Nela Pivac is Senior Scientist, re-elected, at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia andAssociate Professor at the Interdisciplinary PhD study in Osijek
University. She is Associated Editor of Progress in Neuro-Psychopharmacology and Biological Psychiatry, Head of the Laboratory for Molecular Neuropsychiatry,
main Editor of the RBI Annual report, and leader of numerous national and international projects. She has won 4 state awards for scientific achievements and
published 139 scientific papers and 38 chapters in the books, cited 2948 times, H-index=32 and serves as a Reviewer for domestic and international projects and
numerous reputed journals.
Nela Pivac
Rudjer Boskovic Institute, Croatia
Nela Pivac, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C4-044