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Volume 7
Innovative Energy & Research
ISSN: 2576-1463
Advanced Energy Materials 2018
August 13-14, 2018
August 13-14, 2018 | Dublin, Ireland
20
th
International Conference on
Advanced Energy Materials and Research
Innov Ener Res 2018, Volume 7
DOI: 10.4172/2576-1463-C1-003
Cyclic oligosaccharide modification of lanthanide-doped upconversion nanoparticles: as novel
nanostructural drug carriers via host-guest interactions
Jun Ou
Guilin University of Technology, China
Statement of the Problem:
Carbohydrates are biological macromolecules involved in life activities, not only providing energy
and intracellular tissue support, but also mediating the occurrence of inflammatory reactions, affecting cell growth, division,
differentiation, and transduction of intercellular cell signaling. However, low targeted delivery and lack of fluorescent labeling
are two major problems with natural polysaccharide (GA) drugs. The purpose of this study is to describe the experience of
designing a unique pH-sensitive drug carrier based on host-guest interaction between rhodamine and β-cyclodextrin. This
strategy can be extended to other pH-sensitive drug delivery system.
Methodology &Theoretical Orientation:
UCNPs were synthesized following Chemical protocol. Rhodamine was conjugated
with Ganoderma applanatum polysaccharide (GAP) through reductive amination reaction to form rhodamine polysaccharide
complex (R-GAP). The cytotoxicity of CD-UCNPs and R-GAP-CD UCNPs was examined using a methyl thiazolyl diphenyl
tetrazolium (MTT) assay.
Findings:
The UCNPs were synthesized using a typical solvothermal method and UCNPs were modified with β-CD to form a
water-solubility nanocarrier. Rhodamine was conjugated with GAP through reductive amination reaction to form R-GAP so
that it makes the GAP fluorescently trackable. R-GAP was loaded on CD-UCNPs and estimated the drug loading and releasing
behaviors. The results revealed that it was a good pH-sensitive drug carrier and the maximum release amounts of R-GAP reach
up to 67.2% after incubated in PBS for 36 h at pH 5.5.
Conclusion & Significance:
The strategy described in this work is simple and effective to fluorescently mark the GAP and can
enhance the targeting delivery. This article give an evidence to improve natural polysaccharide antitumor drug efficiency by a
proper modifications.
gloujun@glut.edu.cn