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conferenceseries
.com
Volume 09
Journal of Addiction Research & Therapy
Addiction Summit 2018
May 17-18, 2018
May 17-18, 2018 Singapore
8
th
International Conference on
Addictive Disorders and Alcoholism
Factors affecting dose of methadone among patients receiving methadone maintenance therapy: A
retrospective study in Taiwan
Dian-Jeng Li
1
, Hung-Chi Wu
1
and Cheng-Fang Yen
2
1
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Taiwan
2
Kaohsiung Medical University Hospital, Taiwan
Background & Aim:
Methadone has been approved to be an effectively therapeutic strategy for opioid users. However, few
studies had investigated association between dose of Methadone Maintenance Treatment (MMT) and related factors. Our
study aimed to investigate potential factors of them.
Methods:
This retrospective study included newly patients with opioid dependence at outpatient department in the Kaohsiung
Municipal Kai-Syuan Psychiatric Hospital, Taiwan. Primary outcome would be set as daily doses of methadone. The potential
predictors, which were presented with categorical variables, included sex, employment status, present of sleep disorder, and
marital status. Continuous variables as predictors included age, age at initial MMT, educational level, and attendance rates. The
Generalized Estimating Equations (GEEs) were used to analyze the effect of potential variables over time on primary outcome.
Results:
Of the 1290 patients, 85.3% (n=1100) were male, and 36.4% (n=469) of patients were comorbid with sleep disorder.
Patients comorbid with sleep disorder had higher doses of daily methadone than those without sleep disorder (Estimate: 7.03,
P<0.001). Younger age (Estimate: -1.22, P<0.001) and older age at initial MMT (Estimate: 0.44, P<0.001) significantly related
to higher doses of MMT. Furthermore, lower educational level (Estimate: -0.90, P=0.003) and attendance rates (Estimate: -0.14,
P=0.033) significantly associated with higher doses of daily methadone among patients undergoing MMT. For the remaining
variables, all of them did not reached statistical significance.
Conclusion:
We reported that several variables were associated with dose of MMT. Future studies will be necessary to replicate
our findings and extend the universality.
edcrfvm45@hotmail.comJ Addict Res Ther 2018, Volume 9
DOI: 10.4172/2155-6105-C1-037