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History The “Instituto de Neurociencias de Alicante” (IN) was formally founded in February 1990 by the Valencian Regional Government (Generalidad Valenciana), as a University Institute assigned to the University of Alicante. The objectives of that institute were to develop different scientific activities in addition to research, such as a PhD Program, conferences and seminars, and to establish and manage common services and budgets. The Instituto de Neurociencias was then established as an Associated Unit of the Cajal Institute of the Spanish Research Council (CSIC) in 1995, and then together with the Medical School, it was transferred in 1996 to the newly created “Universidad Miguel Hernández de Elche” (UMH). In 1999, the Institute became the Centre "Instituto de Neurociencias", a Joint enterprise of both the UMH and the CSIC with its own building, budget and research facilities. Both institutions, UMH and CSIC, are responsible of the organization and financial support of the Instituto de Neurociencias. The Instituto de Neurociencias provides laboratories, equipment and technical personnel for neurobiological research. It is organized into research units intended to be functional and flexible and serve mainly as an organizational framework to facilitate research activities and stimulate interaction and scientific collaboration among the members of the Institute. The Institute and its members maintain active interchange programs with universities, research centers and neurobiology laboratories around the world. The research groups of the IN employ a wide variety of techniques covering the fields of molecular and cellular biology, genetics and physiology. Among the technical facilities at the INA are fully equipped tissue, cell culture and experimental embryology rooms, optical projection tomography (OPT), confocal and two photon microscopy, and special areas for behavioral experiments. Research Units Developmental Neurobiology • Cell movements in development and disease • Cellular & Molecular Mechanisms of Brain Wiring • Development and assembly of bilateral neural circuits • Developmental Neurogenetics • Early neurogenesis and brain maturation • Experimental Embryology • Interneuron migration: mode and cell signaling • Mechanisms of growth control and cancer in Drosophila. • Molecular Neurogenetics • Neurogenesis and Cortical expansion • Signaling Networks Underlying Asymmetric Cell Division Molecular Neurobiology • Altered molecular mechanism in Alzheimer’s disease and dementia • Biophysics and Pharmacology of ionic channels • Cellular and Behavioral Neuroscience • Cellular plasticity and neuropathology • Mechanisms and receptors involved in analgesy and addiction • Molecular control of neuronal axon myelination • Molecular mechanisms in neurosecretion • Molecular Neurobiology of Neuronal Nicotinic Receptors • Transcriptional and epigenetic mechanisms of neuronal plasticity • Translational neuro psychopharmacology of neurological and psychiatric diseases Cellular and Systems Neurobiology • Behavior of Organisms • Neural Circuits of Social Behavior • Ocular neurobiology • Physiology of prefrontal cortex. Physiology of the Carotid Body • Plasticity of Brain Networks • Sensory transduction and nociception • Sensory-motor processing by subcortical areas • Synaptic Physiology • The Visual Analogy Laboratory
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