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AERAS was founded in 2003 as an independent, not-for-profit research organisation working as a Product Development Partnership (PDP) with scientists, academic institutions, industry, foundations and governments throughout the world to ensure the rapid development and ample distribution of accessible and affordable vaccines to eliminate Tuberculosis (TB). Aeras is a global nonprofit biotech with a mission to develop new tuberculosis vaccines that are affordable and accessible to all who need them. Aeras is a fully integrated, global nonprofit biotech with capabilities in finance, portfolio management, immunology, assay development, clinical trials, regulatory affairs and policy, advocacy and resource mobilization, as well as in-house capacity to conduct pilot manufacturing. Serving as a critical translational bridge from the bench to the field Aeras has sponsored and conducted over 25 clinical vaccine trials enrolling thousands of subjects, and is a key partner in six active clinical development programs. AERAS focuses on advancing lead TB vaccine candidates towards licensure and availability; rationalising the TB development vaccine process; and maintaining a robust TB vaccine portfolio. AERAS is working in TB endemic countries on developing sustainable infrastructure, local capacity building and community outreach to prepare clinical trial sites; and on establishing appropriate manufacturing capacity for each of the vaccines likely to enter late stage (Phase 3) trials. AERAS has worked with others to develop a portfolio of six vaccine candidates which they plan to progress over the next five years. This is the broadest TB vaccine product pipeline in the world. The aim is to license the first new effective TB vaccine in 2015-2016. AERAS research efforts play a significant role in progress towards a number of the Millennium Development Goals. In particular: combating major diseases (both TB and HIV/AIDS), reducing child mortality, and improving maternal health.
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