ISSN 2472-016X
Journal of Orthopedic Oncology
Open Access
Metastatic Bone Cancer
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Metastatic Bone Cancer
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Metastatic Bone Cancer
Metastatic bone cancer occurs when cancer spreads from a primary organ site to bone. The spine is the most common location of metastatic disease. Pain is an important symptom of musculoskeletal metastases, but it is nonspecific. The pain pattern can be helpful if, in addition to being activity related, it is present at rest and at night, especially in patients older than 50 years. Laboratory tests can be used to aid in the diagnosis of metastatic bone cancer.
Related Journals of Metastatic Bone Cancer
Journal of Orthopedic Oncology, Journal of Carcinogenesis & Mutagenesis,Journal of Cancer Science & Therapy, Journal of Leukemia, Archives of Surgical Oncology,Journal of Cancer Clinical Trials, Head and Neck Cancer Research,Journal of Bone Oncology, The Bone & Joint Journal, Journal of Bone and Mineral Research, European Spine Journal, Footwear Science, Spine Deformity.
Metastatic Bone Cancer
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PPT Version | PDF Version - He Wang
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PPT Version | PDF Version - Dr. Sarfraz Ahmad
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Classically, the 3ââ¬â¢untranslated region (3ââ¬â¢UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3ââ¬â¢UTR alone, without all other elements in mRNA such as 5ââ¬â¢UTR and coding region. The importance of independent 3ââ¬â¢UTR RNA (referred as I3ââ¬â¢UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3ââ¬â¢UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3ââ¬â¢UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3ââ¬â¢UTR were important for its tumor suppression activity. Then, the C/EBP 3ââ¬â¢UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3ââ¬â¢UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3ââ¬â¢UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990ââ¬â¢s to 2000ââ¬â¢s, world scientists found several 3ââ¬â¢UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3ââ¬â¢UTR regions, although the existence of their transcribed products as independent 3ââ¬â¢UTR RNAs is still to be confirmed. Our studies indicate that the independent 3ââ¬â¢UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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PPT Version | PDF Version - RanjitaPallavi
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PPT Version | PDF Version - Lourdes Cortes-Dericks
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PPT Version | PDF Version - Mark D Gorrell
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PPT Version | PDF Version - Daniel Rotroff
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PPT Version | PDF Version - Ivan Mfouo-Tynga
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| PDF Version - Masatoshi Kozaki
Construction, Functionalization, and Organization of Dendrimer with Conjugated Backbones
PPT Version | PDF Version - Mark Kester
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PPT Version | PDF Version - Yajun Yi
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PPT Version | PDF Version - Vladimir Pak
Double Targeting as an Effective Anti-Cancer Strategy
PPT Version | PDF Version - Mohammad Hassan
MicroRNA 23a~27a~24-2 cluster regulation of bone formation
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PPT Version | PDF Version - Anton Yuryev
Construction of cancer pathways for personalized medicine
PPT Version | PDF Version - Jung-Joon Min
Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
| PDF Version - Maria Paola COSTI
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PPT Version | PDF Version - Martha M Sklavos
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| PDF Version - Kelvin K. Tsai
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PPT Version | PDF Version - Abeer Kadry El Zohiery
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PPT Version | PDF Version - Zuping Xia
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PPT Version | PDF Version - Juliann G. Kiang
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PPT Version | PDF Version - Charles F. L. Mbakaya
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PPT Version | PDF Version