ISSN 2472-016X

Journal of Orthopedic Oncology
Open Access

Malignant Osteoid

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Malignant Osteoid

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Citations : 61

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Malignant Osteoid

Osteoid is the unmineralized, organic portion of the bone matrix that forms prior to the maturation of bone tissue. Osteoblastic differentiation of the primitive transformed cells produces malignant osteoid, which result in the formation of the malignant primary bone tumour known as Osteosarcoma.

Related Journals of Malignant Osteoid

Journal of Orthopedic Oncology, Orthopedic & Muscular System:Current Research,Journal of Bone Reports & Recommendations,Current Trends in Gynecologic Oncology,Journal of Clinical & Experimental Oncology, Oncology & Cancer Case Reports,Journal of Orthopaedic Trauma, Journal of Orthopaedic Research, Archives of Osteoporosis, Archives of Orthopaedic and Trauma Surgery, Journal of Pediatric Orthopaedics Part B, Journal of Back and Musculoskeletal Rehabilitation, European Journal of Trauma and Emergency Surgery.

Malignant Osteoid

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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Lourdes Cortes-Dericks
    ALDHhigh/CD44+ putative cancer stem cell population as therapeutic target in malignant pleural mesothelioma
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