Journal of Pharmacokinetics & Experimental Therapeutics
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DMPK Studies

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DMPK Studies

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DMPK Studies

DMPK or Drug Metabolism and Pharmacokinetics is a major part of studies related to drugs often referred to as ADME (Absorption, Distribution, Metabolism and Elimination). It is concerned with the study of aspects of absorption, distribution, metabolism and elimination of drug compounds which are administered through any route of administration.

Journals Related to DMPK Studies:

Journal of Pharmacokinetics & Experimental Therapeutics, Drug Metabolism & Toxicology, Research & Reviews: Journal of Pharmaceutical Analysis, Journal of Drug metabolism & Toxicology, European Journal of Drug Metabolism and Pharmacokinetics, Drug Metabolism and Pharmacokinetics.

DMPK Studies

Expert PPTs

Speaker PPTs

  • Muhamed Fakhri Omer
    Cathodoluminescence petrography for provenance studies of the sandstones of Ora Formation (Devonian-Carboniferous), Iraqi Kurdistan Region, Northern Iraq
    PPT Version | PDF Version
  • Mustafa M Hariri
    Importance of methods’ selection in the geosciences studies and exploration
    PPT Version | PDF Version
  • Afsar Rahbar
    Studies of the importance of Cytomegalovirus infection in breast cancer
    PPT Version | PDF Version
  • Jim Polarine
    Case studies of human fl ora and spore contamination in clean rooms
    PPT Version | PDF Version
  • Gulay Yelken Demirel
    Challenges in parenteral formulation development studies and an evaluation from QbD point of view
    PPT Version | PDF Version
  • Jianfeng Hong
    Extractable and leachable studies of parenteral infusion and transfusion products
    PPT Version | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    PPT Version | PDF Version
  • Arny L Blanchard
    Long-term environmental studies and stewardship in Alaska: A case study from Port Valdez
    PPT Version | PDF Version
  • Soha M Hamdy
    Biochemical studies on the effect of turmeric on breast cancer of rats
    PPT Version | PDF Version
  • Adel Nefzi
    “Adel Nefzi-Torrey-Pines-Institute-for-Molecular-Studies-USA-Diversity-Oriented-Synthesis-of-low-Molecular-Weight-Acyclic-and-Heterocyclic-Compounds-from-Resin-bound-Polyamides-Application-for-Drug-Discovery”
    PPT Version | PDF Version
  • Dalia Hussein Soliman
    “Dalia Hussein Soliman-Al-Azhar-University-Egypt-Design-synthesis-docking-and-QSAR-studies-of-novel-3-5-diaryl-pyrazole-derivatives-and-their-evaluation-as-antioxidants-and-as-Immunomodulators-inhibitors-of-TNF-α-IL-2-IL-6”
    PPT Version | PDF Version
  • Xiaomei Lu
    Ocean subsurface studies with the CALIPSO spaceborne lidar
    PPT Version | PDF Version
  • S Catherine Alexander
    Immunotoxicity of industrial effluents in fin fish: An alternative animal model for immunotoxicological studies
    PPT Version | PDF Version
  • Ferdinand N Mbagwu
    Ethnomedical studies of plants used for treatment of diseases in eastern part of Nigeria
    PPT Version | PDF Version
  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
    PPT Version | PDF Version
  • K Padmaja
    Biochemical and therapeutic studies of postpartum indigestion (ppi) in buffaloes
    PPT Version | PDF Version
  • Kishore Kadimpati
    Potential use of Sargassum cinereum biomass for removal of Lead: Kinetics, Isotherms, Thermodynamic and Characterization Studies
    PPT Version | PDF Version
  • Sharda Choudhary
    Molecular studies of Cumin (Cuminumcyminum L.), for diversity and modeling
    PPT Version | PDF Version
  • P Venkataraman
    Impact of rHu-Epo supplementation on CRF induced Neurobehavioral changes in rats: Studies on correlation with APP ratio, β amyloid and pTau expression
    PPT Version | PDF Version
  • Etakula Nagabhushan
    Studies on the Combined Effect of Multi – Walled Carbon Nano Tubes (MWCNTs) and Maleic Anhydride grafted Polypropylene (MA – g PP) on the Mechanical and Thermal Properties of Polypropylene (PP)
    PPT Version | PDF Version
  • Lynda Sharrett Field
    Preclinical studies of glucocorticoid receptor antagonists in the treatment of alcohol dependence
    PPT Version | PDF Version
  • A. E. Pillay
    Laser [213-nm] depth-profiling studies of v/ni ratios in asphaltenes following liquid nitrogen pre-treatment
    PPT Version | PDF Version
  • Nisreen E. Mahmoud
    Parasitological and comparative pathological studies on monogenean infestation of cultured sea bream (Sparus aurata, Sparidae) in Egypt.
    PPT Version | PDF Version
  • Weijia Xie
    Recent structure relationship studies (SAR) on natural occurring sulfonium salts as potent -glucosidase inhibitors
    PPT Version | PDF Version
  • Jeffrey S Patrick
    High Performance Gas Chromatography Mass Spectrometry in Addressing the Challenges of Metabolomic Studies – Separation in Time and Mass
    PPT Version | PDF Version
  • Huseyin Cimen
    Discovery-based Targeted Proteomic Studies: Gel-based and/or off-gel protein sample preparation and purification
    PPT Version | PDF Version
  • Charles F. L. Mbakaya
    Elucidating the link between environment, nutrition, host immunity, AIDS and cancer as informed by selected studies in Kenya and beyond
    PPT Version | PDF Version
  • Subir Samanta
    Design, synthesis and antidiabetic, cardiomyopathy studies of cinnamic acid-amino acid hybrid analogs
    PPT Version | PDF Version
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