Abstract

Fungal keratitis is a severe and potentially sight-threatening infection of the cornea caused by various species of fungi. It poses a significant challenge to ophthalmologists due to its aggressive nature and resistance to conventional treatments. In recent years, Voriconazole eye drops have emerged as a promising therapy for fungal keratitis, offering improved efficacy and better patient outcomes. This article explores the use of Voriconazole eye drops as a treatment option for fungal keratitis, highlighting its mechanism of action, effectiveness, and safety profile. Voriconazole is a novel antifungal agent with excellent broad spectrum activity commercially available for oral and intravenous administration. The purpose of this study was to prepare ophthalmic formulation of hydroxypropyl beta cyclodextrin based voriconazole containing benzalkonium chloride BAK and EDTA with or without viscosity modifiers and study its permeation characteristics through freshly excised goat cornea.