ISSN: 2381-8727

International Journal of Inflammation, Cancer and Integrative Therapy
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  • Research Article   
  • Int J Inflam Cancer Integr Ther, Vol 10(5): 240

Therapeutic Methods and Pancreatic Cancer Stem Cells

Hari Prasad Sonwani*
Department of Pharmacy, Apollo Group of Institution, Durg, India
*Corresponding Author : Hari Prasad Sonwani, Department of Pharmacy, Apollo Group of Institution, Durg, India, Email: harisonwani10@gmail.com

Received Date: Sep 28, 2023 / Published Date: Oct 30, 2023

Abstract

With 1-5% 5-year survival rates (6-month median survival duration) despite medication, pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human malignancies, provides an unmet therapeutic challenge. PDAC accounts for 90% of all pancreatic malignancies and is the most prevalent histological subtype. It is a very aggressive and complex malignancy that manifests with early local invasion and metastasis and is resistant to the majority of treatments, all of which are thought to be factors in its incredibly bad prognosis. PDAC is characterized by molecular changes, including as mutations of the WNT, K-RAS, TP53, Hedgehog, transforming growth factor-, and NOTCH signaling pathways (90% of cases). Given that cancer stem cells play a significant role in medication resistance, the relapse or recurrence of numerous diseases, as well as tumor start and progression. They might make good targets for potent, cutting-edge medicinal strategies. Here, we examined contemporary treatment approaches that use chemotherapeutics and targeted medicines, non-coding RNAs (siRNA and miRNAs), immunotherapy, and natural substances to target pancreatic cancer stem cells.

Citation: Sonwani HP (2023) Therapeutic Methods and Pancreatic Cancer StemCells. Int J Inflam Cancer Integr Ther, 10: 240.

Copyright: © 2023 Sonwani HP. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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