Abstract

Background: Muscle wasting is a significant clinical problem associated with various chronic diseases, including cancer, chronic kidney disease, and heart failure. The underlying mechanisms often involve increased protein catabolism. This case report highlights the role of catabolism in muscle wasting in a patient with chronic heart failure.

Case presentation: We present a 65-year-old male with chronic heart failure who exhibited significant muscle wasting. Clinical assessment, laboratory tests, and muscle biopsy were performed to investigate the underlying mechanisms.

Results: The patient showed elevated levels of catabolic markers, including ubiquitin-proteasome pathway components, and increased inflammatory cytokines. Muscle biopsy revealed reduced muscle fiber cross-sectional area and increased expression of atrophy-related genes.

Conclusion: This case underscores the importance of catabolic pathways in muscle wasting associated with chronic heart failure and highlights potential targets for therapeutic intervention