ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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  • Research Article   
  • J Biotechnol Biomater 2018, Vol 8(4): 287
  • DOI: 10.4172/2155-952X.1000287

Systematical Analysis to Assist the Significance of Rv1907c Gene with the Pathogenic Potentials of Mycobacterium tuberculosis H37Rv

MD Amjad Beg1,2, Shivangi2, Sonu C Thakur1 and Laxman S Meena2*
1Centre for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, Jamia Nagar, New Delhi, India
2CSIR-Institute of Genomics and Integrative Biology, Mall Road, New Delhi, India
*Corresponding Author : Laxman S Meena, CSIR-Institute of Genomics and Integrative Biology, Mall Road, New Delhi, India, Tel: 0091-11-27002200, Email: meena@igib.res.in

Received Date: Dec 03, 2018 / Accepted Date: Dec 27, 2018 / Published Date: Jan 05, 2019

Abstract

Tuberculosis (TB) is currently among the major ten causes for death worldwide being brought about 1.7 million passing in 2016. The singular vaccine candidate available for its treatment till now is Bacillus Calmette-Guerin (BCG) which now also fails to provide accurate protection against this deadly disease. Mycobacterium tuberculosis H37Rv (M. tuberculosis H37Rv), the causative agent of this malady is currently turned out to be so intense and make extremely difficult to treat its infection. This manuscript covers some bioinformatics approaches against conserved hypothetical proteins which pretend to act as a thioredoxin-like protein. Thioredoxin (Trx) proteins are the redox proteins that are rotate between two forms, one is oxidized disulfide and the other one is reduced dithiol forms. Therefore it is said to be as an important component in many cellular redox reactions. The Trx protein of our study contains a conserved motif CXXC which is essential for its enzymatic activity. Mutational analysis of this protein declares its essentiality instability of the protein. This study concludes that this protein might be essential in several cellular processes carried out by this bacterium and further targeting this protein might give us a novel therapeutic antituberculosis drug.

Keywords: Mycobacterium tuberculosis H37Rv; Alveolar macrophages; Phagolysosome; Thioredoxin; Cysteine

Citation: Beg A, Shivangi, Thakur SC and Meena LS (2019) Systematical Analysis to Assist the Significance of Rv1907c Gene with the Pathogenic Potentials of Mycobacterium tuberculosis H37Rv. J Biotechnol Biomater 8:287. Doi: 10.4172/2155-952X.1000287

Copyright: © 2019 Beg A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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