ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Research Article   
  • J Clin Exp Pathol,
  • DOI: 10.4172/2161-0681.1000387

Susceptibility of Community-Acquired Pneumonia in a Han Chinese Population is Associated with Single Nucleoid Polymorphism of rs1840680 in Pentraxin 3 Gene: A Retrospective Case-Control Study

Tiantian Tang1,2, Shiyi Bu1,2, Yingqi Xiao1,3, Qiaojun Zeng1, Biru Huang1, Yumeng Dai1, Zixin Wei1, Linjie Huang1,2*, Phei Er Saw4,5* and Shanping Jiang1,2*
1Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong, China
2Institute of Pulmonary Diseases, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China
3Department of Respiratory Medicine, Tungwah Hospital of Sun Yat-sen University, Dongguan, 523110, China
4Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China
5Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China
*Corresponding Author (s) : Linjie Huang, Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Nanfang College of Sun Yat-sen University, Guangzhou, 510120, Guangdong, China, Email: hlinj@mail.sysu.edu.cn
Phei Er Saw, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China, Email: caipeie@mail.sysu.edu.cn
Shanping Jiang, Department of Pulmonary and Critical Care Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong, China, Email: jiangshp@mail.sysu.eud.cn

Received Date: Jan 05, 2021 / Accepted Date: Jan 19, 2021 / Published Date: Jan 26, 2021

Abstract

Background: Community Acquired Pneumonia (CAP) is increasingly prevalent. Although most patients can be cured after antimicrobial treatment, some individuals may develop acute lung injury or fatal septic shock after rapid disease progression. Genetic variation in the form of Single Nucleoid Polymorphisms (SNPs) of key molecules in innate immunity are related to clinical outcome of Community Acquired Pneumonia (CAP). Pentraxin 3 (PTX3) is one of the key members of the acute-phase reactant superfamily and plays an important role against various diseases.

Objective: The purpose of the current study was to assess the association between SNP in the PTX3 gene andits association with the risk of CAP.

Methods: This is a retrospective case-control study conducted in a department of respiratory medicine of a single medical center. Patients who were diagnosed with CAP based on the criteria of the Chinese Thoracic Society between January 2018 and December 2019 were included as the CAP group. Then CAP cases were matched 1:1 by gender with non-infectious hospitalized patients from the same department during the same time. By using polymerase chain reaction sequencing, we detected the genotypes and determined the allele frequencies and haplotype distributions of three SNPs within the PTX3 gene (rs2305619, rs3816527, and rs1840680) in the CAP and control groups, and compared their associations with the risk of CAP.

Results: Three SNPs in both groups were consistent with Hardy-Weinberg Equilibrium (HWE). A strong linkage disequilibrium was detected between any pair of the SNPs (D’=0.85 for rs2305619 and rs3816527, D’=0.91 for rs2305619 and rs1840680, and D’=0.93 for rs3816527 and rs1840680, respectively). Although there was no significant difference between CAP and control groups for genotypic distribution and haplotype frequency, we determined that SNP rs1840680 AA homozygotes were associated with a lower risk of CAP in adults (OR, 0.32; 95% CI, 0.11-0.91;
p=0.03).

Conclusions: Our findings suggested that PTX3 SNP was associated with the risk of CAP in adults. Translationally, this could mean that a diagnostic method or kit could be developed for rapid detection of SNPs in clinics to reduce the risk of CAP, especially for immunocompromised patients.

Keywords: Community-acquired pneumonia; innate immunity; Pentraxin 3; single nucleotide polymorphisms; rs1840680

Citation: Tang T, Bua S, Xiaoa Y, Zenga Q, Huanga B, et al. (2021) Susceptibility of Community-Acquired Pneumonia in a Han Chinese Population is Associated with Single Nucleoid Polymorphism of rs1840680 in Pentraxin 3 Gene: A Retrospective Case-Control Study. J Clin Exp Pathol 11: 387. Doi: 10.4172/2161-0681.1000387

Copyright: © 2021 Tang T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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