Abstract

The most common type of cannabinoid is the tetra-hydrocannabinol, which is one of the major psychoactive components isolated from Cannabis sativa. Cannabinoids can bind to Gi-protein coupled cannabinoid type 1 receptors, which is highly expressed in the pre- and post-synaptic in brain and spinal cord, as well as the Gi-proteincoupled cannabinoid type 2 receptors that is predominantly located in the immune system. The activation of CB1 and CB2 inhibits the formation of intracellular cAMP, hence leading to a tremendous reduction of the excitatory effect within the neurons.

Keywords: Cannabinoid; Pain sensation; Receptors; Neurokinin;Spinal cord; Pain pathway