Abstract

Opioid overdose continues to be a significant public health crisis, with psychosocial and behavioral factors playing a critical role in both the risk of overdose and the effectiveness of intervention strategies. This article provides a comprehensive review of the key psychosocial and behavioral determinants associated with opioid overdose, including mental health comorbidities, social stigma, trauma history, and socioeconomic factors. The article also examines how these factors influence patterns of opioid use, access to care, and adherence to treatment. It discusses the implications for clinical practice, public health policy, and the development of targeted interventions aimed at reducing overdose risk and improving outcomes for individuals with opioid use disorder (OUD).