ISSN: 2576-3881

Journal of Cytokine Biology
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  • Mini Review Article   
  • J Cytokine Biol,
  • DOI: 10.4172/2576-3881.1000042

Pathophysiologic Similarities between Burn Injury Triggered Systemic Inflammatory Response Syndrome (SIRS) and COVID: Therapeutic Implications from Cytokines and Cells to Hospital Beds

Semih Baghaki*
Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul University-Cerrahpasa, 34700 Fatih, Istanbul, Turkey
*Corresponding Author : Semih Baghaki, Department of Plastic, Department of Plastic, Reconstructive and Aesthetic Surgery, Istanbul University-Cerrahpasa, 34700 Fatih, Istanbul, Turkey, Email: semihbaghaki@gmail.com

Received Date: Jul 02, 2021 / Accepted Date: Jul 16, 2021 / Published Date: Jul 23, 2021

Abstract

Erosion of endothelial surface, disruption of endothelial glycocalyx and hyperinduction of inflammasome complexes are some of the main events taking place in early stages of COVID. Shedding of endothelial glycocalyx is also an important pathophysiologic finding in burn injury. It has also been shown that NLRP3 inflammosome is pivotal in activation of proinflammatory cascades triggered by burn injury which results in propagation to burn Systemic Inflammatory Response Syndrome (SIRS). Disruption of physiologic antithrombotic state of intravascular compartment is a hallmark of COVID. Complement activation especially mannose binding lectin pathway seems to have pivotal role in complement triggered inflammation and thrombotic state. This pathway is also implicated in burn injury triggered Systemic Inflammatory Response Syndrome (SIRS) as part of an innate immunity. Many pathophysiologic aspects of burn SIRS and sepsis share some important characteristics with those of COVID. Therefore, several dimensions of burn management should be implicated and investigated in the treatment of COVID.

Keywords: Systemic inflammatory response syndrome; COVID; Cytokines; Ventilation; Circulation

Citation: Baghaki S (2021) Pathophysiologic Similarities between Burn Injury Triggered Systemic Inflammatory Response Syndrome (SIRS) and COVID: Therapeutic Implications from Cytokines and Cells to Hospital Beds. J Cytokine Biol 6: 42. Doi: 10.4172/2576-3881.1000042

Copyright: © 2021 Baghaki S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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