Abstract

Cytokine gene transfer stands as a promising frontier in cancer therapy, harnessing the genetic machinery to empower the immune system in its battle against malignancies. This abstract delves into the principles, applications, and potential of cytokine gene transfer in cancer treatment. By introducing genes encoding specific cytokines into target cells, this approach aims to stimulate robust anti-tumor immune responses while minimizing systemic toxicities. Mechanisms of action include immune cell activation, anti-tumor immune response enhancement, and angiogenesis inhibition within the tumor microenvironment. Promising applications range from melanoma and glioblastoma to prostate cancer, where cytokine gene transfer shows efficacy in preclinical and clinical settings. Challenges such as vector toxicity and immune rejection underscore the need for continued research and development.