ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(1): 224
  • DOI: 10.4172/2161-119X.1000224

Factors Affecting Recurrence of T1 and T2 Tongue Cancer Undergoing Intraoral Resection

Takeshi Mohri1,2, Yasuhiko Tomita3*, Takashi Fujii2, Miki Tomoeda3, Shota Kotani3, Tomonori Terada1, Nobuo Saeki1, Nobuhiro Uwa1, Kosuke Sagawa1 and Masafumi Sakagami1
1Department of Otolaryngology, Hyogo Medical University, , Japan
2The Departments of Otolaryngology, Osaka Medical Center for Cancer and Cardiovascular Diseases, , Japan
3Departments of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, , Japan
*Corresponding Author : Yasuhiko Tomita MD, PhD, Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi Higashinari-ku, Osaka 537-8511, Japan, Tel: 81-6-6972-1181, Fax: 81-6-6981- 8336, Email: yasuhiko-tomita@umin.ac.jp

Received Date: Feb 03, 2016 / Accepted Date: Feb 16, 2016 / Published Date: Feb 21, 2016

Abstract

1.1. Background: Intraoral resection of early tongue cancer minimally affects the quality of life (QOL) of patients; however, local recurrence of the tumor requires radical resection and negatively affects QOL as well as patient prognosis. The present study was performed to clarify factors affecting recurrence of tongue cancers undergoing intraoral resection.
1.2. Methods: In total, 174 patients (T1: 105 patients and T2: 69 patients) with squamous cell carcinoma of the tongue receiving intraoral resection were enrolled in the study, including 106 male patients and 68 female patients (aged 27-88 years, mean 58 years). Tumor recurrence was observed in 10 of 105 patients with T1 stage cancer (9.5%) and in 6 of 69 patients with T2 stage cancer (8.7%). The clinicopathological factors, including immunohistochemistry for p53, Ki67, and vimentin, were analyzed.
1.3. Results: An infiltration pattern and vimentin expression were associated with tongue cancer recurrence. Specifically, tumors with positive vimentin expression exhibited a higher ratio of endophytic growth, and multivariate analysis revealed that the Ki67 labeling index and vimentin expression were independent factors affecting tumor recurrence.
1.4. Conclusion: The mode of tumor invasion and the epithelial-to-mesenchymal transition, as evidenced by vimentin immunohistochemistry, assisted the identification of high-risk patients with tongue cancer undergoing intraoral resection. Intense follow-up with the aid of multimodal therapies after surgery is necessary in this group of high-risk patients.

Keywords: Tongue cancer, Recurrent, Infiltration gamma, Vimentin expression

Citation: Mohri T, Tomita Y, Fujii T, Tomoeda M, Kotani S, et al. (2016) Factors Affecting Recurrence of T1 and T2 Tongue Cancer Undergoing Intraoral Resection. Otolaryngology 6:224. Doi: 10.4172/2161-119X.1000224

Copyright: © 2016 Mohri T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Triston
    Posted on Oct 26 2016 at 8:57 pm
    This is a well written research article that describes the markers for the identification of high risk patients with tongue cancer receiving intraoral resection. Article is well written and well organized
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