Abstract

Roux-en-Y gastric bypass (RYGB) is a widely performed surgical procedure for treating obesity, which has been associated with changes in the gastrointestinal tract, including the gastric portion. This study aims to evaluate the potential premalignant status of the gastric portion following RYGB in obese women. A retrospective analysis of patients who underwent RYGB was conducted. Patients with a history of gastric malignancy or incomplete followup were excluded. Postoperative assessments included endoscopic examinations and histopathological analyses of gastric tissue samples to detect any premalignant lesions such as intestinal metaplasia or dysplasia. Results indicated that of patients showed specific findings, e.g., absence of premalignant conditions, regression of previously noted lesions. Factors such as weight loss, changes in gastric acidity, and altered microbiome composition post-RYGB were considered in the context of gastric cancer risk reduction. These findings suggest that RYGB may mitigate the potential premalignant status of the gastric portion in obese women by altering gastric physiology and reducing risk factors associated with gastric cancer development. Continued surveillance and long-term follow-up are essential to monitor for any recurrence or new development of premalignant conditions. Further prospective studies are warranted to elucidate the mechanisms underlying these observations and to optimize post-RYGB management strategies aimed at gastric cancer prevention in this population.