ISSN: 2572-4118

Breast Cancer: Current Research
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  • Short Communication   
  • Breast Can Curr Res 2023, Vol 8(4): 4
  • DOI: 10.4172/2572-4118.1000201

Estrogen and BRCA1 Deficiency Work Together to Cause Breast Cancer Mutation-Related DNA Damage

Wenjie Ding*
Vaccine Research Institute Science and Technology, China
*Corresponding Author : Wenjie Ding, Vaccine Research Institute Science and Technology, China, Email: wding@mail.edu.cn

Received Date: Aug 01, 2023 / Published Date: Aug 28, 2023

Abstract

Breast cancer, a complex and heterogeneous disease, is influenced by various genetic, hormonal, and environmental factors. Among these, the interplay between estrogen signaling and the tumor suppressor gene BRCA1 has garnered significant attention due to their individual roles in breast cancer etiology. Estrogen, a pivotal hormone in mammary gland development and function, has been associated with increased breast cancer risk, primarily through its mitogenic and pro-survival effects. On the other hand, BRCA1 plays a critical role in maintaining genomic stability and facilitating DNA repair processes. Mutations in BRCA1 are strongly linked to hereditary breast and ovarian cancers. Recent research suggests a multifaceted interaction between estrogen signaling and BRCA1 function, particularly in the context of DNA damage and repair mechanisms. This review delves into the intricate relationship between estrogen and BRCA1 deficiency, emphasizing their collaborative role in driving breast cancer-associated DNA damage and mutagenesis. We explore the molecular mechanisms through which estrogen can compromise BRCA1-mediated DNA repair, potentially leading to the accumulation of deleterious mutations. Furthermore, we discuss the implications of this synergistic interplay for therapeutic strategies targeting hormone receptor-positive breast cancers with BRCA1 mutations. Enhancing our understanding of how estrogen and BRCA1 deficiency coalesce to promote mutation-related DNA damage is crucial for developing more effective preventive and treatment approaches for breast cancer.

Citation: Ding W (2023) Estrogen and BRCA1 Deficiency Work Together to CauseBreast Cancer Mutation-Related DNA Damage. Breast Can Curr Res 8: 201. Doi: 10.4172/2572-4118.1000201

Copyright: © 2023 Ding W. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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