ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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  • Mini Review   
  • J Clin Exp Pathol 2017, Vol 8(1): 335
  • DOI: 10.4172/2161-0681.1000335

Establishment of Cellular Quiescence Together with H2AX Downregulation and Genome Stability Maintenance

Yusuke Matsuno1,2, Hidetaka Torigoe2 and Ken-ichi Yoshioka1*
1Division of Carcinogenesis and Cancer Prevention and Division of Molecular Modification, National Cancer Center Research Institute, , Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
2Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
*Corresponding Author : Ken-ichi Yoshioka, Division of Carcinogenesis and Cancer Prevention and Division of Molecular Modification, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan, Email: kyoshiok@ncc.go.jp

Received Date: Jan 15, 2018 / Accepted Date: Jan 18, 2018 / Published Date: Jan 22, 2018

Abstract

H2AX is required for genome stability. In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated to form γH2AX foci, which mediate DNA repair and checkpoint signaling. This process is regulated by modifications and molecular interactions of H2AX. In addition, the rapid stabilization of H2AX in response to DSBs facilitates γH2AX foci formation. Although H2AX is markedly downregulated in many cellular states, γH2AX foci can still efficiently form upon DSB generation. Here, we review the regulation of H2AX in response to DSBs.

Keywords: H2AX; γH2AX; DNA double-strand breaks

Citation: Matsuno Y, Torigoe H, Yoshioka K (2018) Establishment of Cellular Quiescence Together with H2AX Downregulation and Genome Stability Maintenance. J Clin Exp Pathol 8: 335. Doi: 10.4172/2161-0681.1000335

Copyright: ©2018 Matsuno Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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