ISSN: 2376-127X

Journal of Pregnancy and Child Health
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  • Research   
  • JPCH,
  • DOI: 10.4172/2376-127X.1000589

Effect of Ferric Sodium EDTA in Combination with Vitamin C, Folic Acid, Copper, Zinc, and Selenium, for Prevention of Iron Deficiency Anemia during Pregnancy

Claudia Guaraldi1, Demetrio Costantino1, Annalisa Curcio2*, Fabiana Nano2, Adriana Romano3 and Michele Pironti2
1"Centro salute Donna", Azienda USL, Ferrara, Italy
2Medical Department, Aqma Italia S.p.A., Naples, Italy
3Medical Department, Merqurio Pharma S.r.l., Naples, Italy
*Corresponding Author : Annalisa Curcio, Medical Department, Aqma Italia S.p.A., Naples, Italy, Email: annalisa.curcio@aqma.it

Received Date: Apr 03, 2023 / Accepted Date: Apr 28, 2023 / Published Date: Apr 28, 2023

Abstract

During pregnancy iron requirement increases for meet the needs of mother and fetus development and growth. Often iron stores of pregnant women are not sufficient, inducing a major risk of occurrence of iron deficiency (ID) and iron deficiency anemia (IDA), that have been associated with major risk of adverse pregnancy outcomes. The aim of this study was to verify the effect of the administration of 1 tablet a day of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine (Ferachel Forte®), on the hematological status of pregnant women, with reference to the prevention of IDA in pregnancy. Pregnant non-anemic women (N=100) were enrolled and randomized to treatment with Ferric Sodium EDTA combination (Group A, N=50) or with folic acid (Group B, N=50). Blood parameters of hemoglobin (Hb), total number of red blood cells (RBCs), ferritin, and transferrin were evaluated at T0: before starting therapy (<12th week), T1 at 20-24 weeks, T2 at 30-32 weeks, and T3 at 36 weeks. Degree of tolerability in treatment group and adverse events eventually reported were added as evaluation of safety. Results showed that Group A maintained almost unchanged blood parameters evaluated and the therapy was effective to prevent IDA on A. Group B results showed a worsening statistically significant (P < 0.001) of all parameters evaluated. In Group a most women reported that treatment was safe and well tolerated. In conclusion, this study confirmed the efficacy and safety of supplementation with Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate, and selenomethionine (Ferachel Forte®), for preventing anemia in pregnant women.

Citation: Guaraldi C, Costantino D, Curcio A, Nano F, Romano A, et al. (2023) Effect of Ferric Sodium EDTA in Combination with Vitamin C, Folic Acid, Copper, Zinc, and Selenium, for Prevention of Iron Deficiency Anemia during Pregnancy. J Preg Child Health 10: 589. Doi: 10.4172/2376-127X.1000589

Copyright: © 2023 Guaraldi C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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