Abstract

Wound healing properties of Mesenchymal Stem Cells (MSC) is a topic of great interest and their mechanism of action is mainly attributed to their paracrine effects and their potential to differentiate in the area of contact, thereby resulting in wound healing. Umbilical Cord (UCMSC) derived MSC and Bone marrow derived MSC (BM MSC) are both good candidates for wound healing. However the ease in procuring UCMSC makes it an attractive candidate for wound healing. The capabilities of both MSC towards wound healing is not elucidated clearly and hence we undertake this study to compare UC MSC and BM MSC supernatants and measure certain key cytokines. We also compare its differentiation properties at different passages and study if both these properties are interlinked. We found that UC MSC retains its differentiation properties better than BM MSC, and that their paracrine capabilities seem to be interlinked with their differentiation potencies.

Keywords: Wound healing; Mesenchymal stem cells; Paracrine effect; UCMSC; Bone marrow; Cytokine profile