Abstract

Obese people are more likely to develop a variety of cancers, including colorectal and liver cancers, and chronic inflammatory conditions have been linked to this association. In a cross-link axis between obesity and colorectal cancer (CRC), we are attempting to determine the clinical relevance of the mechanisms controlling the expression of microRNAs (miR-215 and miR-146a) and transforming growth factor (TGF)/interleukin-6 (IL-6) The participants in the study were split into four groups: wholesome controls; without colorectal cancer, obese; non-obese colorectal cancer; and overweight with colon cancer. Cancer biomarkers like carcinoembryonic antigen (CEA), carbohydrate antigen 19.9 (CA19.9), and alpha-fetoprotein (AFP) levels were significantly higher in obese and CRC patients. In obese colorectal cancer patients, the relative expression of the microRNAs miR-215 and miR-146a was significantly lower. The correlation between BMI and the microRNAs miR-215 and miR-146a was significant and negative. TGF- had a positive effect on IL-6, cholesterol, triglyceride levels, and body mass index (BMI). High blood levels of TGF- and IL-6 indicate how intensely obesity-related inflammation develops, which may raise the risk of colorectal cancer.