Abstract

Chemical genetics is a burgeoning field that integrates chemical tools with genetic techniques to probe and manipulate biological systems at the molecular level. This approach enables researchers to uncover intricate molecular pathways and elucidate gene functions through small molecules, offering a powerful complement to traditional genetic and biochemical methods. This review provides an overview of chemical genetics, highlighting its principles, applications, and recent advancements. By bridging chemistry and genetics, chemical genetics holds promise for accelerating discoveries in molecular biology and drug development.