Abstract

Skeletal muscle injuries resulting from trauma, disease, or aging can lead to functional impairment and decreased quality of life. Biomaterial-based approaches offer promising solutions for promoting skeletal muscle regeneration by providing structural support, delivering bioactive factors, and facilitating cellular interactions within the injured tissue microenvironment. Biomaterial scaffolds designed for skeletal muscle regeneration exhibit tailored properties to mimic the native Extracellular Matrix (ECM), including biocompatibility, biodegradability, mechanical strength, and the ability to support cell adhesion and proliferation. Various biomaterials, such as natural polymers (e.g., collagen, fibrin, alginate) and synthetic polymers (e.g., polyesters, polycaprolactone), have been explored for their ability to promote myogenesis, angiogenesis, and tissue integration. This abstract provides an overview of recent advancements in biomaterials for skeletal muscle regeneration, highlighting their design principles, applications, and translational potential.