ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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  • Research Article   
  • J Anal Bioanal Tech 2018, Vol 9(2): 404
  • DOI: 10.4172/2155-9872.1000404

Application of a DNA Deafness Microarray for Detecting Mutations in the Deaf in Vietnam

Nguyen Thi Trang* and Vu To Giang
Department of Biomedical and Genetics, Hanoi Medical University, Hanoi, Vietnam
*Corresponding Author : Nguyen Thi Trang, Department of Biomedical and Genetics, Hanoi Medical University, N.1, Ton That Tung, Dong Da, Hanoi, Vietnam, Tel: +841638788736, Email: trangnguyen@hmu.edu.vn

Received Date: Apr 09, 2018 / Accepted Date: Apr 16, 2018 / Published Date: Apr 20, 2018

Abstract

Object: To identify the presentation of deafness-related gene caused non-syndromic hearing loss in Vietnamese children.
Methods: Apply DNA microarray to 250 hearing-impaired and 250 normal children in Hanoi to screen nine mutational hot spots of four deafness genes, namely GJB2, GJB3, SLC26A4, and 12S rRNA.
Results: there are 16 hearing loss participants carried mutations, account for 6.4% in comparison with 0 % of control group. The carrier rates of GJB2, GJB3, SLC26A4, 12S rRNA mutations were 4.4%, 0%, 1.2% and 0.8% respectively.
Conclusion: Early detection of common deafness mutations is a factor for diagnosing and rescuing, helping hearing-loss children to develop their language and awareness normally. Microarray testing is a helpful and instrumental screening method in the diagnosis of genetic hearing loss.

Keywords: DNA microarray; Non-syndromic hearing loss; GJB2; GJB3; SLC26A4; 12S rRNA

Citation: Trang NT, Giang VT (2018) Application of a DNA Deafness Microarray for Detecting Mutations in the Deaf in Vietnam. J Anal Bioanal Tech 9: 404. Doi: 10.4172/2155-9872.1000404

Copyright: © 2018 Trang NT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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