ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngology 2012, Vol 2(2)
  • DOI: 10.4172/2161-119X.S3-003

Affective Processing in Tinnitus Patients Assessed by Functional Magnetic Resonance Imaging

Petra Georgiewa1, Georg Bohner2, Yvonne Rothemund1, Randolf Klingebiel2, Heidi Olze3, Burghard F. Klapp1 and Birgit Mazurek4*
1Department of Medicine, Division of Psychosomatic Medicine and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, , Berlin, Germany
2Neuroradiology Section, Department of Radiology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, , Germany
3Department of Otorhinolaryngology, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, , Germany
4Department of Otorhinolaryngology, Tinnitus Centre, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, , Germany
*Corresponding Author : Birgit Mazurek MD, PhD, Department of Otorhinolaryngology, Tinnitus Centre, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany, Tel: +49-30- 450555009, Fax: +49-30-450555942, Email: birgit.mazurek@charite.de

Received Date: Mar 27, 2012 / Accepted Date: May 23, 2012 / Published Date: May 28, 2012

Abstract

Background: Brain imaging studies suggested that the functional connectivity of various limbic, prefrontal, and temporal brain structures may play an important role in tinnitus.

Methods: We evaluated in affective processing of tinnitus patients by functional Magnetic Resonance Imaging (fMRI). Patients with tinnitus and healthy controls underwent fMRI (1.5 T scanner) during 4 blocks of auditory stimuli of different emotional quality: 1) unpleasant beep tones, 2) pleasant sounds of chimes, 3) neutral words, 4) words with affective valence, alternating with off-periods.

Results: The comparison of activation patterns (Statistical Parametric Mapping SPM 99) revealed significant differences in the limbic system, in prefrontal regions, temporal association cortices and striatal regions independent of affective relevance of stimuli.

Conclusion: Our results underline a differing affective perception of acoustic stimuli in tinnitus patients.

Citation: Georgiewa P, Bohner G, Rothemund Y, Klingebiel R, Olze H, et al. (2012) Affective Processing in Tinnitus Patients Assessed by Functional Magnetic Resonance Imaging. Otolaryngology S3:003. Doi: 10.4172/2161-119X.S3-003

Copyright: © 2012 Georgiewa P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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