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Pediatric population represents a changing and dynamic population due to the ontogenetic changes that occur during
their development. As it has been observed that, pediatrics does not deal with miniature adults, with reduced doses and
has its own independent range and horizon. So prescribing the medication for pediatric population is a unique challenge
as their anatomy and physiology is completely different from adults. In particular, age-related changes in gastrointestinal
(GI) physiology (transit time, pH, GI fluid composition, specifically bile salt concentrations) and in intestinal/hepatic drug
metabolizing enzymes, as well as formulation parameters (dose volume, solubility) can contribute to differential absorption of
orally administered drugs in children versus adults. For example, oral bioavailability of the potent antifungal lipophilic drug,
voriconazole, in children (2-10 years) is almost half that in adults (45-65% versus 96%). The present study describes the facts
and current scenario in formulation development aspects for pediatric populations and determining various factors responsible
for variable bioavailability of pediatric medicaments in children. Absorptive transport of pediatric drugs was measured across
intestinal tissue using Using-type diffusion chamber as a function of Fasted-State Simulated Intestinal Fluid (FaSSIF) with
variable bile salt concentration. Dissolutions studies were determined of the model drugs as a function of volume and media
with variable bile salt concentrations. It was found that dissolution and absorptive transport of model drugs has reduced rate
of dissolution and variable absorptive transport. Thus, normalization of the adult dose may lead to poor and unsafe estimates
of the pediatric dose.