Journal of Clinical & Experimental Pathology
Open Access

Abstract

Adenomatoid odontogenic tumor (AOT) is always a benign tumor with rare incidence of recurrence while ameloblastoma is the commonest gnathic tumor which is always aggressive. Although co-occurrence of these lesions has been reported, this paper describes a homogenous combination of â�?�?atypicalâ�? AOT and ameloblastomatous proliferation with some malignant microscopic features. To date, about 16 cases of this uncommon composite odontogenic tumor have been, quite correctly, reported in the literature under the designation of â�?�?Adenoid ameloblastomaâ�?. Of these, neither has revealed cellular atypia nor plemorphism. This extremely rare ameloblastomatous variant can pose a significant diagnostic challenge. Moreover, there were some findings of severe nuclear vacuolization, mitotic figures, cellular polymorphism and nuclear hyperchromatism and chromatin peripheralization. However, the scattered occurrence of these was not sufficient for claiming a malignancy. To confirm the ameloblatic origin and detect the lesional potential, two immunohistochemical markers claretinin and p53 were recruited. Rendering itself to be suspicious, a rapt attention should be paid toward interrogating the cases of adenoid ameloblastoma histologically and immunohistochemically.

Biography

Email: bacemottoman@gmail.com