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Hindi Review Article
Zebrafish as a New Platform Used in Exploration of Ketamine-Induced Neurodevelopmental Toxicity
Wei Zhou1, Zhengshang Ruan1, Bo Xu1, Zhiyu Chen1, Zirong Huo1, Lixia Li2 and Bin He1*1Department of Anesthesia and SICU, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China
2Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China
- *Corresponding Author:
- Bin He
Department of Anesthesia and SICU
Xinhua Hospital, Shanghai Jiaotong University
Shanghai 200092,china
Tel: 8615000330960
E-mail: hebinicu@139.com
Received Date: February 20, 2015; Accepted Date: April 27, 2015; Published Date: April 30, 2015
Citation: Zhou W,Ruan Z,Xu B,Chen Z, et al. (2015) Zebrafish as a New Platform Used in Exploration of Ketamine-Induced Neurodevelopmental Toxicity. J Clin Exp Pathol 5:225. doi: 10.4172/2161-0681.1000225
Copyright: © 2015 Zhou W, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
We have modified the abstract as ‘Previous studies have already found out that commonly used anesthetic, ketamine, has toxic effects on neurodevelopment. Unlike most rodent models just focusing on neuronal apoptosis caused by ketamine, early stages of neuron development abnormality in zebrafish can be assessed in vivo because of the transparent embryos and larve. And also thanks to its cost-efficiency and quick reproduction, large-scale behavior analyses and gene screens can be conducted in zebrafish. Besides, the whole genome of zebrafish has already been sequenced and its gene functions are highly conserved during evolution, which makes the experiments more reliable on zebrafish model. So Zebrafish has obvious advantages in the researches of ketamine neurotoxicity over the conventional animal models (such as mice). Within this paper we illuminate how we can use this model to study ketamine neurotoxicity. In the future, along with more advanced genetic technologies joining this platform will not only make up for conventional models to deeply understand neurodevelopmental toxicity of ketamine, but also might provide the unique insight to the field of neurodevelopment and neurotoxicity impaired by other drugs
