Abstract

Yolk sac tumors are rare malignant neoplasms predominantly found in the ovaries and testes, with occurrence in the endometrium being exceedingly uncommon, particularly in post-menopausal women. Here, we present a case report of a yolk sac tumor identified within the endometrium of a post-menopausal woman. The patient presented with atypical uterine bleeding and was subsequently diagnosed through histopathological examination following endometrial biopsy. We discuss the clinical presentation, diagnostic challenges, treatment modalities, and prognostic factors associated with yolk sac tumors of the endometrium, supplemented by a comprehensive review of the existing literature. Additionally, we highlight the importance of considering yolk sac tumors in the differential diagnosis of endometrial pathology, especially in post-menopausal women, and discuss the implications for patient management and prognosis. This case underscores the significance of heightened clinical awareness and multidisciplinary collaboration in the management of rare gynecological malignancies, facilitating timely diagnosis and optimal therapeutic interventions for improved patient outcomes