Abstract

Estimation of breast cancer risk for a woman who does not have a personal history of invasive breast cancer or ductal carcinoma in situ begins with an initial assessment of familial/genetic factors associated with increased breast cancer risk for the purpose of determining whether more extensive genetic risk assessment and counselling should be undertaken. The first step in this primary assessment is a broad and flexible evaluation of the personal and family history of the individual, primarily with respect to breast and/or ovarian cancer/fallopian tube or primary peritoneal cancer.

Keywords: Genetic component; General population; Inheritance patterns; Sporadic cancer; Penetrance genes; Weight gain