Abstract

Enteropathogenic Escherichia coli (EPEC) is a common pathogen responsible for gastrointestinal infections. The interaction between EPEC and white blood cells (WBCs) is crucial in understanding the immune response against EPEC infection. This abstract summarizes the key findings regarding the interaction between EPEC and WBC single layers. EPEC infection leads to the formation of attaching and effacing (A/E) lesions on intestinal epithelial cells. Neutrophils and macrophages, as part of the innate immune response, play significant roles in combating EPEC infection. EPEC can adhere to and invade WBCs through specific adhesins and type III secretion system, respectively. The interaction triggers an immune response characterized by the release of pro-inflammatory cytokines, chemokines, and reactive oxygen species. WBCs employ various mechanisms such as phagocytosis, antimicrobial peptide release, and neutrophil extracellular trap formation to eliminate EPEC. However, EPEC can manipulate the immune response by inhibiting cytokine production, impairing chemotaxis, and disrupting neutrophil extracellular traps. Understanding these interactions provides insights into EPEC pathogenesis and aids in the development of effective strategies to combat EPEC-induced infections. Further research is required to uncover the intricate mechanisms and develop targeted interventions against EPEC and related pathogens.