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Hindi Virus-Associated Hemophagocytic Syndrome Caused by Influenza B and Varicella-Zoster Virus Co-Infection
*Corresponding Author: Dongning Yan, Third Hospital of Gansu Province, Gansu University of Chinese Medicine, 35 Dingxidonglu, 730000, Lanzhou, China, Email: 1908584753@qq.comReceived Date: Apr 23, 2024 / Published Date: May 24, 2024
Citation: Chen X, Wang Y, and Yan D (2024) Virus-Associated Hemophagocytic Syndrome Caused by Influenza B and Varicella-Zoster Virus Co- Infection . J Infect Dis Ther S6:005.DOI: 10.4173/2332-0877.24.S6.005
Copyright: © 2024 Chen X et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Varicella (chicken pox), which caused by the Varicella-Zoster Virus (VZV), is usually self-limiting and benign. However, VZV can lead to significant and serious complications, especially in immunocompromised patients or accompanied by other pathogens infection. HPS caused by varicella-zoster and influ B virus co-infection is rare.
Case presentation: A 15-years-old boy was admitted to our hospital because of general rash, severe back and low back pain. CT scan revealed pneumonia in left upper lobe. Initial blood tests showed normal blood WBC and PLT, mild liver dysfunction, enhanced D-dimer and myocardial enzyme. However, after 4-days treatment of acyclovir, antibiotics, and analgesic therapy, his pain did not relieved and fever developed. At the same time, hyperferritinemia, abrupt reduction on blood WBC and PLT count were observed. Virus-Associated Hemophagocytic Syndrome (VHAS) was confirmed. Then, intravenous drip dexamethasone (10 mg/day) and gamma globulin (10 g/day) were administrated. He recovered completely at last.
Conclusions: Disseminated Varicella which was accompanied by influenza B virus and bacteria infection is infrequent. Disseminated varicella may cause significant morbidity and even mortality in immunocompromised patients. Hemophilic syndrome induced by duel-virus and bacteria infection is limited and usually fetal. Anti-bacterial therapy, early identification of this syndrome and timely administration of glucocorticoids and gamma globulin are the key links of treatments.
