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  • Research Article   
  • Epidemiol Sci,

Viral Dynamics and Ct Value Distribution with Age and Gender of COVID-19 Patients in a Tertiary Care Hospital Lahore, Pakistan

Aasia Khaliq1, Fouzia Ashraf1*, Saamia Tahir2, Shahzeb Javed3, Saher Shahid4 and Huda Abbas1
1Department of Pathology and Microbiology, Allama Iqbal Medical College, Lahore, Pakistan
2Department of Biochemistry, University of Health Sciences, Lahore, Pakistan
3Department of Community Medicine, Combined Military Hospital, Lahore, Pakistan
4School of Biological Sciences, University of the Punjab, Lahore, Pakistan
*Corresponding Author : Fouzia Ashraf, Department of Pathology and Microbiology, Allama Iqbal Medical College, Lahore, Pakistan, Email: pcrjinnah@yahoo.com

Received Date: Mar 22, 2021 / Accepted Date: Apr 05, 2021 / Published Date: Apr 12, 2021

Abstract

This was a retrospective study of 2,956 cases detected positive by RT-PCR to observe the viral dynamics in different age groups and gender using Ct value of COVID-19 patients, 78% cases were detected positive for ORF1ab and E gene, 15% cases were positive for ORF1ab and N gene while 8% cases were positive only for ORF1ab. The mean, median and 95% CI of Ct for ORF1ab were all numerically higher than the comparative value of E gene (mean, 27.26 vs. 26.31; median, 27.51 vs. 26.93 and 95% CI 26.92-27.60 vs. 25.98-26.63) p-value <0.0001 and N gene (mean, 35.22 vs. 29.58; median, 36.86 vs. 29.55 and 95% CI 34.65-35.0 vs. 29.33-29.82) p-value <0.0001. Nonparametric t-test showed no statistical difference in the viral load or density between male and female patients. When comparing different age groups, viral load at the age of 45-55 years and >65 years was quantitatively higher in female as compared to male patients with p-value 0.0399 and 0.0328 respectively. In conclusion, more men (65%) were infected as compared to female patients. Also the viral load or disease was more severe in male patients than female (36% vs. 24%) at the reproductive age group of 25-34 years.

Keywords: COVID-19; Viral dynamics; Cycle threshold; OPR1ab; N gene

Citation: Khaliq A, Ashraf F, Tahir S, Javed S, Shahid S, et al. (2021) Viral Dynamics and Ct Value Distribution with Age and Gender of COVID-19 Patients in a Tertiary Care Hospital Lahore, Pakistan. Epidemiol Sci 11: 403.

Copyright: © 2021 Khaliq A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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