Abstract

Huntington's disease (HD) is a hereditary neurodegenerative condition that significantly impacts individuals' lives, leading to cognitive, motor, and emotional changes. Particularly in later stages, individuals with HD may exhibit behaviours that are distressing to both professionals and caregivers, such as aggression, impulsivity, and inappropriate comments. Despite the absence of a specific formulation framework tailored to HD, clinical formulation-a personalized approach utilized by mental health professionals to articulate an individual's challenges-has proven valuable in conceptualizing patients' well-being.

Existing evidence highlights the efficacy of formulation in guiding clinical interventions, enhancing consistency across multidisciplinary teams, refining risk management strategies, and fostering empathy and understanding among staff and caregivers. Consequently, this paper proposes a novel clinical formulation model for comprehensively understanding distress among individuals with HD, grounded in a biopsychosocial framework.