Abstract

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. The search for effective treatments has been hindered by the limitations of current animal models, which often fail to replicate the complexity of human AD. Bearded capuchin monkeys (Sapajus libidinosus) present a promising alternative due to their advanced cognitive abilities, social behaviors, and neuroanatomical similarities to humans. This article explores the potential of using bearded capuchin monkeys as models for AD research, highlighting their advantages over traditional rodent models, the methodologies employed, and the challenges faced. Ethical considerations, the need for enhanced genetic tools, and the integration of behavioral and neurobiological studies are discussed as critical factors in leveraging capuchin monkeys for AD research. The findings suggest that capuchin monkeys could significantly advance our understanding of Alzheimer’s disease and contribute to the development of more effective therapies.