ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Short Communication   
  • J Infect Dis Ther,
  • DOI: 10.4172/2332-0877.1000490

Unvaccinated Convalescent Person with Previous Covid-19 Infection had Low Immunity Response: An Important Clinical Information

Le Ngoc Hung1,2*, Nguyen Huu Tung1,2, Cao Hung Phu1, Nguyen Van Bac1 and Nguyen Manh Hoa1
1Department of Infection, Tam Tri Sai Gon General Hospital, Ho Chi Minh City, Vietnam
2Department of Infection, Phan Chu Trinh University, Quáng Nam, Vietnam
*Corresponding Author : Dr. Le Ngoc Hung, Department of Infection, Tam Tri Sai Gon General Hospital, Ho Chi Minh City, Vietnam, Email: hung.le.d12@tmmchealthcare.com

Received Date: Jan 13, 2022 / Published Date: Feb 07, 2022

Abstract

When the worldwide population enters the period of vaccination against SARS-CoV-2 infection, the more information on immune response, the better for the prevention strategy against COVID-19. We reported herein the results of SARS-CoV-2 antibodies in a cross-sectional study 75 Vietnamese participants divided into 3 groups: Auninfected person with 2 doses vaccination (“Vac” group; n=32); B: convalescent person who received first dose vaccine then having COVID-19 infection (“Vac-F0” group; n=12); and C: unvaccinated convalescent person with previous COVID-19 infection (“F0” group; n=31). The “F0” group had 26% (8/31) with antibodies higher than 250 U/mL, significantly lower than those from “Vac” group (84.4%, 27/32) and “Vac-F0” group (83.3%, 10/12), p=0.000. There were 3 cases in “F0” group with “no immune response” (<0.4 U/mL, 9.7%). No difference in antibodies between “Vac” and “Vac-F0” group. Among “F0” group, “non-severe infection” person had immune response lower than that from whom with severe infection (p=0.04). Unvaccinated convalescent person with previous infection had low immunity against SARS-CoV-2 virus. The antibody measurement is essential to identify this at-risk population and an additional dose of vaccine is needed for them.

Keywords: COVID-19; Unvaccinated covalescent person; Anti -SARSCoV-2;Spike antibody

Citation:  Hung LN, Tung NH, Phu CH, Bac NV, Hoa NM (2022) Unvaccinated Convalescent Person with Previous Covid-19 Infection had Low Immunity Response: An Important Clinical Information. J Infect Dis Ther 10:490. Doi: 10.4172/2332-0877.1000490

Copyright: © 2022 Hung LN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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