Abstract

This review explores a paradigm-shifting concept in the realm of oncology—harnessing cancer cells to activate cancer-specific protective immunity. Cancer, with its elusive nature and ability to evade immune defenses, has long posed a formidable challenge. The article delves into the intriguing dynamics of reprogramming the body’s immune mechanisms to recognize and combat cancer cells. From fundamental principles to the latest breakthroughs, the review navigates the landscape of activating cancer-specific protective immunity, focusing on checkpoint inhibitors, adoptive cell therapies, and cancer vaccines. These innovative approaches promise to revolutionize cancer treatment strategies by unleashing the body’s own defense mechanisms against this relentless adversary.