Abstract

Pharmacokinetic variability among individuals poses significant challenges in clinical practice, influencing drug efficacy and safety. This variability arises from genetic, physiological, and environmental factors, impacting drug absorption, distribution, metabolism, and excretion (ADME). Understanding these complexities is crucial for tailoring therapy to individual patients, optimizing drug dosing, and minimizing adverse effects. This article explores the implications of pharmacokinetic variability on therapeutic outcomes, highlighting the importance of personalized medicine and strategies such as pharmacogenetic testing and therapeutic drug monitoring (TDM) in clinical practice.