Abstract

Epithelial protein loss is a complex phenomenon implicated in both normal physiological processes and cancer pathogenesis. This review aims to comprehensively analyze the mechanisms underlying epithelial protein loss in neoplasms, exploring its role in promoting tumorigenesis and metastasis. Key pathways and molecular interactions involved in regulating epithelial protein homeostasis are discussed, highlighting potential therapeutic targets. By elucidating the intricate connections between epithelial protein loss and cancer progression, this review aims to provide insights into novel strategies for diagnosis, prognosis, and treatment of epithelial-derived malignancies.