Abstract

Tuberculosis (TB) of the central nervous system (CNS) is a highly devastating form of TB especially in endemic country such as Tunisia. We aimed to present four different cases of CNS TB to demonstrate the large spectrum of Neurotuberculosis (NTB) clinical manifestations in Tunisian population. Main features described were tuberculous meningitis, tuberculoma, and spinal tuberculous. There were currently no real diagnostic tools to distinguish NTB from differential diagnosis. NTB diagnosis was based on strong clinical and radiological evidence followed by an adequate response to anti tubercular treatment. Standardized diagnosis criteria need to be established for the different clinical categories in order to be uniformly applicable in NTB diagnosis and management.

Keywords: Tuberculosis; Central Nervous System; Meningitis