Abstract

Alzheimer’s disease (AD) is one of the most common conditions in elderly people with a high prevalence of dementia at roughly 60 – 80. The pathogenesis of AD was relatively complicated and presently there's no unified conclusion in the academic community, so no efficiently clinical treatment is available. In recent years, with the development of traditional Chinese drug (TCM), experimenters have proposed the idea of relying on TCM to prevent and treat AD based on the specific of multiple targets of TCM. This study reviewed the pathological thesis of AD and the implicit biomarkers set up in the current researches. And the implicit targets of berberine and evodiamine from Evodia rutaecarpa in AD were summarized and further anatomized. A emulsion- targets- pathway network was carried out to clarify the medium of action of berberine and evodiamine for AD. Likewise, the limitations of current inquiries on the TCM and AD were discussed. It's hoped that this review will give some references for development of TCM in the prevention and treatment of AD.