Abstract

Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. However, the poor bioavailability and stability of curcumin have been major limitations. In response to this challenge, researchers have explored different methods to enhance its pharmacological properties, including the hydrogenation of curcumin. In this article, we present a toxicological evaluation of a standardized hydrogenated extract of curcumin to assess its safety for potential therapeutic applications. Two mortalities occurred in the main and satellite high-dose groups and were determined due to gavage error.