ISSN: 2572-0406

Journal of Chemical Biology & Therapeutics
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Case Study   
  • J Chem Biol Ther 2017, Vol 2(1): 114
  • DOI: 10.4172/2572-0406.1000114

Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment

Gérard Slama1,2*, Laurence Slama3, Jacques Blacher1, Joël Sebbah4, Yves El Bèze2, Serge Gryner1 and Stanislas Pol5
1Centre de Diagnostics et de Thérapeutique, AP-HP, Hôtel-Dieu Hospital and Paris Descartes University, , Paris, France
2Centre Médical Bastille, , 5 bis, Place de la Bastille 75004 Paris, France
3Service de Thérapeutique en Immuno-Infectiologie, Hôtel-Dieu Hospital, , Paris, France
4Institut Médical Montsouris, , 42, boulevard Jourdan 75014 Paris, France
5Hepatology Department, Cochin Hospital, Paris Descartes University, Inserm U1223, Institut Pasteur, Paris, France
*Corresponding Author : Gérard Slama MD, Centre de Diagnostics et de Thérapeutique, AP-HP, Hôtel-Dieu Hospital and Descartes University, 85, Avenue Du Général Leclerc 75014, Paris, France, Email: geslama@wanadoo.fr

Received Date: Sep 15, 2017 / Accepted Date: Sep 25, 2017 / Published Date: Sep 29, 2017

Abstract

Cardiac dysrhythmias (atrial and/or ventricular fibrillation) represent a major medical problem, with possibly life-threatening complications, necessitating costly, life-long treatments or complicated procedures. We report here a case of a sustained correction of a severe and long-standing atrial dysrhythmia (hyperexcitability) and at a lesser degree, a ventricular hyperexcitability, occurring after treatment with a combination of sofosbuvir plus ledispavir administered to treat a chronic Hepatitis C virus infection (HCV). The correction appeared within the first days of anti-HCV treatment and was totally maintained 3 months after drug cessation and still noticeable 3 more months. The mechanism of such an antiarrhythmic action has still to be elucidated. If confirmed, the potential antiarrhythmic effect of sofosbuvir combined with another antiviral drug, could represent a real advance in atrial and maybe ventricular hyperexcitability treatment.

Keywords: Cardiac arrhythmia; Atrial fibrillation; Extrasystoles; Sofosbuvir; Ledispavir; HCV

Citation: Slama G, Slama L, Blacher J, Sebbah J, Bèze YE, et al. (2017) Total or Sub-Total Correction of a Marked and Long-standing Cardiac Dysrhythmia after Sofosbuvir/Ledispavir Treatment. J Chem Biol Ther 2: 114. Doi: 10.4172/2572-0406.1000114

Copyright: © 2017 Slama G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top